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Article

Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright.

The EMBO journal - 18 Mar 2009

Schmidt Christian, Kim Dongkyoon, Ippolito Gregory C, Naqvi Hassan R, Probst Loren, Mathur Shawn, Rosas-Acosta German, Wilson Van G, Oldham Athenia L, Poenie Martin, Webb Carol F, Tucker Philip W

Abstract excerpt

Regulation of BCR signalling strength is crucial for B-cell development and function. Bright is a B-cell-restricted factor that complexes with Bruton's tyrosine kinase (Btk) and its substrate, transcription initiation factor-I (TFII-I), to activate immunoglobulin heavy chain gene transcription in...

Read the complete abstract on PubMed

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Share to Agammaglobulinaemia Tyrosine Kinase
Share to Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin M

Share to Lipoylation

Share to Membrane Microdomains

Share to Receptors, Antigen, B-Cell

Share to Small Ubiquitin-Related Modifier Proteins

Share to Transcription Factors, TFII

Source

Open in PubMed Open full text

Identifiers

PMID: 19214191
DOI: 10.1038/emboj.2009.20
PMCID: PMC2666038

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19214191-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright.PMID 19214191Read ↗

Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.Semantic proximity Read ↗

Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function.Semantic proximity Read ↗

Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.Semantic proximity Read ↗

E41K Mutation Activates Bruton’s Tyrosine Kinase by Stabilizing an Inositol Hexakisphosphate dependent Invisible DimerSemantic proximity Read ↗

Signalling of Bruton's Tyrosine Kinase, BtkSemantic proximity Read ↗

Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in miceSemantic proximity Read ↗

Amplification of IL-21 signalling pathway through Bruton’s tyrosine kinase in human B cell activationSemantic proximity Read ↗

Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics.Semantic proximity Read ↗

STING couples with PI3K to regulate actin reorganization during BCR activationSemantic proximity Read ↗

Regulation of Nuclear Localization and Transcriptional Activity of TFII-I by Bruton’s Tyrosine KinaseSemantic proximity Read ↗

Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes.Semantic proximity Read ↗

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