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Article

Unexpected autocrine role of vascular endothelial growth factor in squamous cell carcinoma.

The Journal of investigative dermatology - 1 Mar 2009

Arbiser Jack L

Abstract excerpt

Mirones et al. demonstrate that keratinocytes deficient in VEGF are capable of forming tumors but use a distinct form of aneuploidy and signaling to form tumors. This knowledge is important because inhibitors of VEGF, including bevacizumab (anti-VEGF antibodies) and sorafenib (Braf/VEGFR2 kinase inhibitor), have already entered the clinic. These agents may "remodel" tumor signaling.

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Source

Identifiers

PMID: 19209155
DOI: 10.1038/jid.2008.427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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