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Article

Conserved rhodopsin intradiscal structural motifs mediate stabilization: effects of zinc.

Biochemistry - 3 Mar 2009

Gleim Scott, Stojanovic Aleksandar, Arehart Eric, Byington Daniel, Hwa John

Abstract excerpt

Retinitis pigmentosa (RP), a neurodegenerative disorder, can arise from single point mutations in rhodopsin, leading to a cascade of protein instability, misfolding, aggregation, rod cell death, retinal degeneration, and ultimately blindness. Divalent cations, such as zinc and copper, have allost...

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Identifiers

PMID: 19206210
DOI: 10.1021/bi800968w
PMCID: PMC2765562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19206210-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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