Article
The natural history of type 1A diabetes.
Arquivos brasileiros de endocrinologia e metabologia - 1 Mar 2008
Eisenbarth George S, Jeffrey Joy
Abstract excerpt
We can now predict the development of Type 1A (Immune Mediated) diabetes primarily through the determination of four biochemically characterized islet autoantibodies [insulin, GAD65, IA-2 (ICA512) and (Znt8)]. Prediction is possible because beta-cell destruction is chronically progressive and very slow in most, but not all individuals. We can also prevent type 1A diabetes in animal models and a major goal is the...
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