Article
Hepatitis B virus basal core promoter mutation and DNA load correlate with expression of hepatitis B core antigen in patients with chronic hepatitis B.
The Journal of infectious diseases - 1 Mar 2009
Liu Chun-Jen, Jeng Yung-Ming, Chen Chi-Lin, Cheng Huei-Ru, Chen Pei-Jer, Chen Ting-Chi, Liu Chen-Hua, Lai Ming-Yang, Chen Ding-Shinn, Kao Jia-Horng
Abstract excerpt
BACKGROUND: Expression of intrahepatic hepatitis B core antigen (HBcAg) is related to the immunopathogenesis of hepatitis B virus (HBV) infection. This study investigated the role that HBV genotype and basal core promoter (BCP) mutation play in the expression of HBcAg. METHODS: A total of 70 hepatitis B e antigen (HBeAg)-positive patients with chronic hepatitis (genotype B in 52 patients and genotype C in 18...
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