Article
Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations.
Nature genetics - 1 Apr 2009
Gudmundsson Julius, Sulem Patrick, Gudbjartsson Daniel F, Jonasson Jon G, Sigurdsson Asgeir, Bergthorsson Jon T, He Huiling, Blondal Thorarinn, Geller Frank, Jakobsdottir Margret, Magnusdottir Droplaug N, Matthiasdottir Sigurborg, Stacey Simon N, Skarphedinsson Oskar B, Helgadottir Hafdis, Li Wei, Nagy Rebecca, Aguillo Esperanza, Faure Eduardo, Prats Enrique, Saez Berta, Martinez Mariano, Eyjolfsson Gudmundur I, Bjornsdottir Unnur S, Holm Hilma, Kristjansson Kristleifur, Frigge Michael L, Kristvinsson Hoskuldur, Gulcher Jeffrey R, Jonsson Thorvaldur, Rafnar Thorunn, Hjartarsson Hannes, Mayordomo Jose I, de la Chapelle Albert, Hrafnkelsson Jon, Thorsteinsdottir Unnur, Kong Augustine, Stefansson Kari
Abstract excerpt
In order to search for sequence variants conferring risk of thyroid cancer we conducted a genome-wide association study in 192 and 37,196 Icelandic cases and controls, respectively, followed by a replication study in individuals of European descent. Here we show that two common variants, located on 9q22.33 and 14q13.3, are associated with the disease. Overall, the strongest association signals were observed for...
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