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Article

Pivotal role of mast cells in pruritogenesis in patients with myeloproliferative disorders.

Blood - 4 Jun 2009

Ishii Takefumi, Wang Jiapeng, Zhang Wei, Mascarenhas John, Hoffman Ronald, Dai Ying, Wisch Nathaniel, Xu Mingjiang

Abstract excerpt

Pruritus is a common symptom in patients with Philadelphia chromosome-negative myeloproliferative disorders (MPDs). The pathophysiology of MPD-associated pruritus is unclear. We have demonstrated that MPD mast cells (MCs) are involved by the malignant process. In the present study, we explored the hypothesis that MCs play an important role in the development of pruritogenesis in MPDs. We found that MPD MCs...

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Identifiers

PMID: 19196660
DOI: 10.1182/blood-2008-09-179416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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