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Article

Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis

24 Apr 2020

Abstract excerpt

Abstract Alcohol consumption is a consistent protective factor for the development of autoimmune diseases such as rheumatoid arthritis (RA). The underlying mechanism for this tolerance-inducing effect of alcohol, however, is unknown. Here we show that alcohol and its metabolite acetate alter the functional state of T follicular helper (TFH) cells in vitro and in vivo, thereby exerting immune regulatory and...

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PMID: 32332730
DOI: 10.1038/s41467-020-15855-z

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