Use of in vitro fertilization and embryo transfer to circumvent infertility caused by an inherited imperforate vagina in mice.

Abstract excerpt

An autosomal recessive mutation (ipv) causing infertility in homozygous females (ipv/ipv) because of imperforate vaginae was discovered in a line of mice selected for low lean tissue mass as a proportion of body weight. The aim of this study was to determine if the mutation could be propagated in offspring following embryo transfer of oocytes collected from mutant females and fertilized in vitro with sperm from...

Topics

• Animals
• Embryo Transfer
• Female
• Fertilization in Vitro
• Genes, Recessive
• Infertility, Female
• Male
• Mice
• Mutation
• Vagina