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Male mice produced by in vitro culture have reduced fertility and transmit organomegaly and glucose intolerance to their male offspring.

Biology of reproduction - 1 Aug 2012

Calle Alexandra, Miranda Alberto, Fernandez-Gonzalez Raul, Pericuesta Eva, Laguna Ricardo, Gutierrez-Adan Alfonso

Abstract excerpt

It has been reported that suboptimal in vitro culture (IVC) of mouse embryos can affect the postnatal expression of epigenetically sensitive alleles, resulting in altered postnatal growth, organ dimensions, health, and behavior in the offspring. Although these detrimental impacts on the offspring are well described, the relative contribution of the IVC-produced fathers is unclear. In this work, we have analyzed...

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PMID: 22649070
DOI: 10.1095/biolreprod.112.100743

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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