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Article

Actin homolog MreB affects chromosome segregation by regulating topoisomerase IV in Escherichia coli.

Molecular cell - 30 Jan 2009

Madabhushi Ram, Marians Kenneth J

Abstract excerpt

In Escherichia coli, topoisomerase IV, a type II topoisomerase, mediates the resolution of topological linkages between replicated daughter chromosomes and is essential for chromosome segregation. Topo IV activity is restricted to only a short interval late in the cell cycle. However, the mechanism that confers this temporal regulation is unknown. Here we report that the bacterial actin homolog MreB participates...

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Share to DNA Topoisomerase IV
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Segregation

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Share to Gene Expression Regulation, Bacterial

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Identifiers

PMID: 19187760
DOI: 10.1016/j.molcel.2009.01.001
PMCID: PMC2759193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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