Article
Amino acid discrimination by arginyl-tRNA synthetases as revealed by an examination of natural specificity variants.
The FEBS journal - 1 Mar 2009
Igloi Gabor L, Schiefermayr Elfriede
Abstract excerpt
L-canavanine occurs as a toxic non-protein amino acid in more than 1500 leguminous plants. One mechanism of its toxicity is its incorporation into proteins, replacing L-arginine and giving rise to functionally aberrant polypeptides. A comparison between the recombinant arginyl-tRNA synthetases from a canavanine producer (jack bean) and from a related non-producer (soybean) provided an opportunity to study the...
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