Article
Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC).
Clinical and experimental medicine - 1 Jun 2009
Tahara Tomomitsu, Shibata Tomoyuki, Nakamura Masakatsu, Yamashita Hiromi, Yoshioka Daisuke, Okubo Masaaki, Maruyama Naoko, Kamano Toshiaki, Kamiya Yoshio, Fujita Hiroshi, Nakagawa Yoshihito, Nagasaka Mitsuo, Iwata Masami, Takahama Kazuya, Watanabe Makoto, Nakano Hiroshi, Hirata Ichiro, Arisawa Tomiyasu
Abstract excerpt
Tryptase acting at protease-activated receptor 2 (PAR2) contributes to the pathogenesis of Inflammatory bowel diseases (IBDs). DNA methylation has been shown to be an important mechanism in gene silencing. We attempted to clarify the relationship between the promoter methylation of PAR2 and ulcerative colitis (UC). 84 UC patients enrolled in the study. UC patients were classified by disease behavior, severity and...
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