[Influence of mutations of proteinase-activated receptors F2R/PAR1 and F2RL1/PAR2 on inflammatory bowel disease].

Abstract excerpt

BACKGROUND AND OBJECTIVE: Inflammatory bowel disease (IBD) is a polygenic complex trait. The expression and presence in biopsiae from IBD patients points to a putative role of these genes in genetic susceptibility to IBD. This is the first association study on these genes in relation with IBD. PATIENTS AND METHOD: Two polymorphisms were analyzed within F2R/PAR1 and another one mapping to F2RL1/PAR2 in 778 healthy...

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