Article
The distinct gene expression profiles of chronic lymphocytic leukemia and multiple myeloma suggest different anti-apoptotic mechanisms but predict only some differences in phenotype.
Leukemia research - 1 Sept 2003
Zent Clive S, Zhan Fenghuang, Schichman Steven A, Bumm Klaus H W, Lin Pei, Chen James B, Shaughnessy John D
Abstract excerpt
We compared gene expression in purified tumor cells from untreated patients with chronic lymphocytic (CLL) (n=24) and newly diagnosed multiple myeloma (MM) (n=29) using the Affymetrix HuGeneFL microarray with probes for approximately 6800 genes. Hierarchical clustering analysis showed that CLL and MM have distinct expression profiles (class prediction). Gene and protein expression (measured by flow cytometry)...
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