Article
Abnormal binding of factor VIII is linked with the substitution of glutamine for arginine 91 in von Willebrand factor in a variant form of von Willebrand disease.
The Journal of biological chemistry - 15 Oct 1991
Kroner P A, Friedman K D, Fahs S A, Scott J P, Montgomery R R
Abstract excerpt
von Willebrand factor (vWf) is a multimeric plasma glycoprotein that functions in hemostasis as the initiator of platelet adhesion to damaged blood vessels and as the carrier of Factor VIII (FVIII). Montgomery et al. (Montgomery, R.R., Hathaway, W.E., Johnson, J., Jacobsen, L., and Muntean, W. (1...
Topics
- Arginine
- Autoradiography
- Base Sequence
- Cell Line
- Electrophoresis, Polyacrylamide Gel
- Factor VIII
- Gene Expression
- Glutamine
- Humans
- Molecular Sequence Data
- Mutation
- Polymorphism, Genetic
- RNA, Messenger
- von Willebrand Diseases
- von Willebrand Factor