Article
Characterization of recombinant von Willebrand factor corresponding to mutations in type IIA and type IIB von Willebrand disease.
The Journal of biological chemistry - 15 Nov 1992
Ribba A S, Voorberg J, Meyer D, Pannekoek H, Pietu G
Abstract excerpt
Type IIA and IIB von Willebrand disease (vWD) result from defects in von Willebrand factor (vWF). Although both type IIA and IIB vWD are characterized by the absence of high molecular weight multimers in plasma, vWF from patients with type IIA vWD demonstrates a decreased affinity for the platele...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Base Sequence
- Blood Platelets
- Cloning, Molecular
- Humans
- Kinetics
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Oligodeoxyribonucleotides
- Plasmids
- Platelet Membrane Glycoproteins
- Recombinant Proteins
- Ristocetin
- von Willebrand Factor