Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of recombinant von Willebrand factor corresponding to mutations in type IIA and type IIB von Willebrand disease.

The Journal of biological chemistry - 15 Nov 1992

Ribba A S, Voorberg J, Meyer D, Pannekoek H, Pietu G

Abstract excerpt

Type IIA and IIB von Willebrand disease (vWD) result from defects in von Willebrand factor (vWF). Although both type IIA and IIB vWD are characterized by the absence of high molecular weight multimers in plasma, vWF from patients with type IIA vWD demonstrates a decreased affinity for the platelet receptor glycoprotein Ib (GPIb), whereas vWF from patients with type IIB vWD show an increased affinity for GPIb. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Kinetics

Share to Molecular Sequence Data

Share to Mutation

Share to Plasmids

Share to Recombinant Proteins

Source

Identifiers

PMID: 1429668

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of recombinant von Willebrand factor corresponding to mutations in type IIA and type IIB von Willebrand disease.PMID 1429668Read ↗

Characterization of Leu777Pro and Ile865Thr type IIA von Willebrand disease mutations.Semantic proximity Read ↗

Recombinant von Willebrand factor Arg578-->Gln. A type IIB von Willebrand disease mutation affects binding to glycoprotein Ib but not to collagen or heparin.Semantic proximity Read ↗

Leu 697-->Val mutation in mature von Willebrand factor is responsible for type IIB von Willebrand disease.Semantic proximity Read ↗

Molecular diagosis of von Willebrand disease.Semantic proximity Read ↗

Discrepancy between IIA phenotype and IIB genotype in a patient with a variant of von Willebrand disease.Semantic proximity Read ↗

Molecular study of von Willebrand disease: identification of potential mutations in patients with type IIA and type IIB.Semantic proximity Read ↗

Identification and functional analysis of a novel von Willebrand factor mutation in a family with type 2A von Willebrand disease.Semantic proximity Read ↗

Type 2A (IIH) von Willebrand disease is due to mutations that affect von Willebrand factor multimerization.Semantic proximity Read ↗

Impaired intracellular transport produced by a subset of type IIA von Willebrand disease mutations.Semantic proximity Read ↗

Characterization of a novel mutation in the von Willebrand factor propeptide in a distinct subtype of recessive von Willebrand disease.Semantic proximity Read ↗

Functional analysis of a type IIB von Willebrand disease missense mutation: increased binding of large von Willebrand factor multimers to platelets.Semantic proximity Read ↗

Expression and characterization of von Willebrand factor dimerization defects in different types of von Willebrand disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.