Article
Molecular characterization of a unique von Willebrand disease variant. A novel mutation affecting von Willebrand factor/factor VIII interaction.
The Journal of biological chemistry - 25 Jul 1991
Cacheris P M, Nichols W C, Ginsburg D
Abstract excerpt
von Willebrand factor (vWF) plays a central role in blood coagulation, mediating the adhesion of the initial platelet plug to the subendothelium, and serving as the carrier for factor VIII (FVIII) in the circulation. In previous studies, we have mapped the epitope for an anti-vWF monoclonal antib...
Topics
- Adult
- Base Sequence
- Binding Sites
- Factor VIII
- Female
- Humans
- Molecular Sequence Data
- Mutation
- Oligonucleotides
- Polymerase Chain Reaction
- von Willebrand Diseases
- von Willebrand Factor