Article
Aberrant heparan sulfate proteoglycan localization, despite normal exostosin, in central chondrosarcoma.
The American journal of pathology - 1 Mar 2009
Schrage Yvonne M, Hameetman Liesbeth, Szuhai Karoly, Cleton-Jansen Anne-Marie, Taminiau Antonie H M, Hogendoorn Pancras C W, Bovée Judith V M G
Abstract excerpt
The tumor suppressor genes EXT1 and EXT2 are involved in the formation of multiple osteochondromas, which can progress to become secondary peripheral chondrosarcomas. The most common chondrosarcoma subtype is primary central chondrosarcoma, which occurs in the medullar cavity of bone. The EXT1/EXT2 protein complex is involved in heparan sulfate proteoglycan (HSPG) biosynthesis, which is important for signal...
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