Article
Peripheral chondrosarcoma progression is associated with increased type X collagen and vascularisation.
Virchows Archiv : an international journal of pathology - 1 Jan 2012
de Andrea Carlos E, Wiweger Malgorzata I, Bovée Judith V M G, Romeo Salvatore, Hogendoorn Pancras C W
Abstract excerpt
Endochondral bone formation requires a cartilage template, known as the growth plate, and vascular invasion, bringing osteoblasts and osteoclasts. Endochondral chondrocytes undergo sequences of cell division, matrix secretion, cell hypertrophy, apoptosis, and matrix calcification/mineralisation. In this study, two critical steps of endochondral bone formation, the deposition of collagen X-rich matrix and blood...
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