Article
Epiphyseal growth plate and secondary peripheral chondrosarcoma: the neighbours matter.
The Journal of pathology - 1 Jan 2012
de Andrea Carlos E, Hogendoorn Pancras C W
Abstract excerpt
Chondrocytes interact with their neighbours through their cartilaginous extracellular matrix (ECM). Chondrocyte-matrix interactions compensate the lack of cell-cell contact and are modulated by proteoglycans and other molecules. The epiphyseal growth plate is a highly organized tissue responsible for long bone elongation. The growth plate is regulated by gradients of morphogens that are established by...
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