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Article

Splice-site pairing is an intrinsically high fidelity process

29 Jan 2009

Abstract excerpt

The extensive alternative splicing in higher eukaryotes has initiated a debate whether alternative mRNA isoforms are generated by an inaccurate spliceosome or are the consequence of highly degenerate splice sites within the human genome. Here, we established a quantitative assay to evaluate the accuracy of splice-site pairing by determining the number of incorrect exon-skipping events made from constitutively...

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PMID: 19179398
DOI: 10.1073/pnas.0813128106

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