PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population.

doi:10.1111/j.1365-2265.2008.03465.x

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Article

PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population.

Clinical endocrinology - 1 Sept 2009

Osawa Haruhiko, Tabara Yasuharu, Kawamoto Ryuichi, Ohashi Jun, Ochi Masaaki, Onuma Hiroshi, Nishida Wataru, Yamada Kazuya, Nakura Jun, Miki Tetsuro, Makino Hideichi, Kohara Katsuhiko

Abstract excerpt

OBJECTIVE: The Ala allele of the Pro12Ala polymorphism (rs1801282) of peroxisome proliferator-activated receptor gamma (PPARgamma) is protective against type 2 diabetes (T2DM). Resistin, secreted from adipocytes, causes insulin resistance in rodents. Resistin gene expression is reduced by the PPARgamma ligand. We previously reported that subjects with the G/G genotype of a resistin gene single nucleotide...

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PMID: 19178525
DOI: 10.1111/j.1365-2265.2008.03465.x

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PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes are synergistically associated with plasma resistin in the Japanese general population.PMID 19178525Read ↗

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