Article
PCR/LDR/capillary electrophoresis for detection of single-nucleotide differences between fetal and maternal DNA in maternal plasma.
Prenatal diagnosis - 1 Mar 2009
Yi Ping, Chen Zhuqin, Zhao Yan, Guo Jianxin, Fu Huabin, Zhou Yuanguo, Yu Lili, Li Li
Abstract excerpt
BACKGROUND: The discovery of fetal DNA in maternal plasma has opened up an approach for noninvasive diagnosis. We have now assessed the possibility of detecting single-nucleotide differences between fetal and maternal DNA in maternal plasma by polymerase chain reaction (PCR)/ligase detection reaction((LDR)/capillary electrophoresis. METHODS: PCR/LDR/capillary electrophoresis was applied to detect the genotype of...
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