Article
Prenatal detection of beta-thalassemia CD17 (A-->T) mutation by polymerase chain reaction/ligase detection reaction/capillary electrophoresis for fetal DNA in maternal plasma--a case report.
Fetal diagnosis and therapy - 1 Jan 2010
Yi Ping, Chen Zhuqin, Yu Lili, Zheng Yingru, Xie Haichang, Zheng Xiuhui, Liu Qiang, Han Jian, Li Li
Abstract excerpt
OBJECTIVES: It was the aim of this study to investigate the feasibility of polymerase chain reaction (PCR)/ligase detection reaction (LDR)/capillary electrophoresis for the detection of paternally inherited fetal CD17 (A-->T) mutation of beta-thalassemia in maternal plasma. METHODS: The target DNA in maternal plasma was amplified by PCR and the mutant signal was detected by LDR. Unique LDR products were produced...
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