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The soluble metal-binding domain of the copper transporter ATP7B binds and detoxifies cisplatin

28 Jan 2009

Abstract excerpt

Wilson disease ATPase (ATP7B) has been implicated in the resistance of cancer cells to cisplatin. Using a simple in vivo assay in bacterial culture, in the present study we demonstrate that ATP7B can confer resistance to cisplatin by sequestering the drug in its N-terminal metal-binding domain without active drug extrusion from the cell. Expression of a protein fragment containing four N-terminal MBRs...

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PMID: 19173677
DOI: 10.1042/bj20081359

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