Article
Lack of association between optineurin gene variants T34T, E50K, M98K, 691_692insAG and R545Q and primary open angle glaucoma in Brazilian patients.
Ophthalmic genetics - 1 Mar 2009
Caixeta-Umbelino Cristiano, de Vasconcellos José Paulo Cabral, Costa Vital Paulino, Kasahara Niro, Della Paolera Maurício, de Almeida Geraldo Vicente, Cohen Ralph, Mandia Carmo, Rocha Mylene Neves, Richeti Flávio, Longui Carlos Alberto, de Melo Mônica Barbosa
Abstract excerpt
PURPOSE: To verify the frequencies of T34T, E50K, M98K, 691_692insAG, and R545Q variants in the optineurin (OPTN) gene in Brazilian subjects with primary open-angle glaucoma (POAG) and controls. PATIENTS AND METHODS: Ninety-nine patients with POAG and 100 normal controls were enrolled in this study. The frequency of alterations in the OPTN gene was analyzed by direct sequencing and enzymatic digestion of PCR...
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