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Article

A Highly Proliferative Group IIC Intron from Geobacillus stearothermophilus Reveals New Features of Group II Intron Mobility and Splicing.

Journal of molecular biology - 17 Aug 2018

Mohr Georg, Kang Sean Yoon-Seo, Park Seung Kuk, Qin Yidan, Grohman Jacob, Yao Jun, Stamos Jennifer L, Lambowitz Alan M

Abstract excerpt

The thermostable Geobacillus stearothermophilus GsI-IIC intron is among the few bacterial group II introns found to proliferate to high copy number in its host genome. Here, we developed a bacterial genetic assay for retrohoming and biochemical assays for protein-dependent and self-splicing of GsI-IIC. We found that GsI-IIC, like other group IIC introns, retrohomes into sites having a 5'-exon DNA hairpin,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29913158
DOI: 10.1016/j.jmb.2018.06.019
PMCID: PMC6082379

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