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Salmonella enterica serovar Typhimurium mutants unable to convert malate to pyruvate and oxaloacetate are avirulent and immunogenic in BALB/c mice.

Infection and immunity - 1 Apr 2009

Mercado-Lubo Regino, Leatham Mary P, Conway Tyrrell, Cohen Paul S

Abstract excerpt

Previously, we showed that the Salmonella enterica serovar Typhimurium SR-11 tricarboxylic acid (TCA) cycle must operate as a complete cycle for full virulence after oral infection of BALB/c mice (M. Tchawa Yimga, M. P. Leatham, J. H. Allen, D. C. Laux, T. Conway, and P. S. Cohen, Infect. Immun. 74:1130-1140, 2006). In the same study, we showed that for full virulence, malate must be converted to both...

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PMID: 19168732
DOI: 10.1128/IAI.01335-08
PMCID: PMC2663132

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Source receipt: pubmed, retrieved 6 Sept 2026.

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