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Article

The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction.

Molecular human reproduction - 1 Mar 2009

Kusz K M, Tomczyk L, Sajek M, Spik A, Latos-Bielenska A, Jedrzejczak P, Pawelczyk L, Jaruzelska J

Abstract excerpt

The highly conserved Nanos gene was found to encode a translational repressor necessary for germ-cell development in lower organisms. The mammalian homologue, Nanos2, was recently found to be expressed in the mouse germ cells. Since its disruption caused infertility exclusively in males, we sought to study the significance of this gene in human male reproduction. Here, we describe for the first time the...

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Identifiers

PMID: 19168545
DOI: 10.1093/molehr/gap003

Genes

NANOS2

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The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction.PMID 19168545Read ↗

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A male infertility mutation reverts NANOS1 activity from anti-apoptotic to pro-apoptotic by disrupting repression of <i>GADD45A</i> , <i>GADD45B</i> , <i>GADD45G</i> and <i>RHOB</i> genesSemantic proximity Read ↗

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