Article
A role for transcription factor NF-kappaB in autoimmunity: possible interactions of genes, sex, and the immune response.
Advances in physiology education - 1 Dec 2006
Dale Elizabeth, Davis Miriam, Faustman Denise L
Abstract excerpt
Sex hormones have long been implicated in autoimmune diseases because women account for 80% of cases. The mechanism of hormonal action in autoimmunity is unknown. Drawing on genetic studies of autoimmune disease, this article discusses how both genes and sex hormones may exert their effects through the same general mechanism, dysregulation of transcription factor NF-kappaB, an immunoregulatory protein. Gene and...
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