Article
Alteration of ocular surface mucins in MUC5AC-DTA transgenic mice.
Molecular vision - 1 Jan 2009
Wang I-Jong, Yu Chong-Jen, Hu Fung-Rong
Abstract excerpt
PURPOSE: To investigate the compensation of secretory mucins with membranous mucins in mice with goblet cell deficiency. METHODS: A transgenic mouse model in which conjunctival goblet cells were targeted was generated, and the expression of mucins was evaluated through the toxicity of diphtheria toxin A driven by a human mucin, MUC5AC, promoter. Immunohistochemical staining, in situ hybridization, electronic...
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