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Article

Detection of known base substitution mutations in human mitochondrial DNA of MERRF and MELAS by biochip technology.

Biosensors & bioelectronics - 15 Apr 2009

Du Weidong, Li Wei, Chen Gang, Cao Huimin, Tang Huayang, Tang Xianfa, Jin Qinghui, Sun Zhongwu, Zhao Hui, Zhou Wenming, He Sumin, Lv Yongmei, Zhao Jianlong, Zhang Xuejun

Abstract excerpt

We developed a DNA biochip specialized for detection of known base substitution mutations in mitochondrial DNA causing mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) and myoclonic epilepsy associated with ragged-red fibers (MERRF). A set of probes sharing a given allele-specific sequence with a single base substitution near the middle of the sequence was covalently immobilized....

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Share to Base Pair Mismatch
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19155171
DOI: 10.1016/j.bios.2008.12.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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