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Article

[Development of a DNA biochip for detection of known mtDNA mutations associated with MELAS and MERRF syndromes.].

Yi chuan = Hereditas - 1 Oct 2008

Chen Gang, Li Wei, DU Wei-Dong, Cao Hui-Min, Tang Hua-Yang, Tang Xian-Fa, Sun Zhong-Wu, Zhao Hui, Jin Qing-Hui, Zhao Jian-Long, Zhang Xue-Jun

Abstract excerpt

We developed an oligonucleotide biochip for synchronous multiplex detection of 31 known mitochondrial DNA mutations associated with MELAS (Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) and MERRF (Myoclonic epilepsy with ragged red fibers). Allele-specific oligonucleotide probes were covalently immobilized on aldehyde modified glass slides, and then hybridized with Cy5-labled DNA...

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Identifiers

PMID: 18930887
DOI: 10.3724/sp.j.1005.2008.01279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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