Article
Overlapping sense and antisense transcription units in Trypanosoma brucei.
Molecular microbiology - 1 May 2001
Liniger M, Bodenmüller K, Pays E, Gallati S, Roditi I
Abstract excerpt
Procyclins are the major surface glycoproteins of insect-form Trypanosoma brucei. The procyclin expression sites are polycistronic and are transcribed by an alpha-amanitin-resistant polymerase, probably RNA polymerase I (Pol I). The expression sites are flanked by transcription units that are sensitive to alpha-amanitin, which is a hallmark of Pol II-driven transcription. We have analysed a region of 9.5 kb...
Topics
- 3' Untranslated Regions
- Animals
- DNA, Antisense
- Gene Expression Regulation
- Glycoproteins
- Microtubule-Associated Proteins
- Molecular Sequence Data
- Mutation
- Protozoan Proteins
- RNA Polymerase I
- Sequence Analysis, DNA