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Article

Synergistic effect of polymorphisms of paraoxonase gene cluster and arsenic exposure on electrocardiogram abnormality.

Toxicology and applied pharmacology - 1 Sept 2009

Liao Ya-Tang, Li Wan-Fen, Chen Chien-Jen, Prineas Ronald J, Chen Wei J, Zhang Zhu-Ming, Sun Chien-Wen, Wang Shu-Li

Abstract excerpt

Arsenic has been linked to increased prevalence of cancer and cardiovascular disease (CVD), but the long-term impact of arsenic exposure remains unclear. Human paraoxonase (PON1) is a high-density lipoprotein-associated antioxidant enzyme which hydrolyzes oxidized lipids and is thought to be protective against atherosclerosis, but evidence remains limited to case-control studies. Only recently have genes encoding...

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Source

Identifiers

PMID: 19152805
DOI: 10.1016/j.taap.2008.12.017

Genes

PON1
PON2
GSTO1
GSTO2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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