Article
Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2.
Neurobiology of disease - 1 Mar 2009
Chung Wendy K, Shin Minyoung, Jaramillo Thomas C, Leibel Rudolph L, LeDuc Charles A, Fischer Stuart G, Tzilianos Efthia, Gheith Ayman A, Lewis Alan S, Chetkovich Dane M
Abstract excerpt
Analysis of naturally occurring mutations that cause seizures in rodents has advanced understanding of the molecular mechanisms underlying epilepsy. Abnormalities of I(h) and h channel expression have been found in many animal models of absence epilepsy. We characterized a novel spontaneous mutant mouse, apathetic (ap/ap), and identified the ap mutation as a 4 base pair insertion within the coding region of Hcn2,...
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