Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resistance to paclitaxel therapy is related with Bcl-2 expression through an estrogen receptor mediated pathway in breast cancer

1 Jan 1992

Abstract excerpt

Taxanes are approved for the treatment of breast cancer that has spread to the lymph nodes, following surgery and doxorubicin containing chemotherapy. Taxanes have improved the survival of breast cancer patients, especially in estrogen receptor (ER) negative population in clinical settings. This time we examined the relationship between chemosensitivity to Taxanes and expresson of ERalpha in breast cancer cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Treatment and Pharmacology
Share to Estrogen and related hormone effects
Share to HER2/EGFR in Cancer Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19148464
DOI: 10.3892/ijo_00000153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resistance to paclitaxel therapy is related with Bcl-2 expression through an estrogen receptor mediated pathway in breast cancerPMID 19148464Read ↗

Roles of the Bcl-2/Bax Ratio, Caspase-8 and 9 in Resistance of Breast Cancer Cells to PaclitaxelSemantic proximity Read ↗

Alteration of the Mitochondrial Apoptotic Pathway Is Key to Acquired Paclitaxel Resistance and Can Be Reversed by ABT-737Semantic proximity Read ↗

BCL-2 Hypermethylation Is a Potential Biomarker of Sensitivity to Antimitotic Chemotherapy in Endocrine-Resistant Breast CancerSemantic proximity Read ↗

Regulators of apoptosis in human breast cancer.Semantic proximity Read ↗

Breast cancer cells respond differently to docetaxel depending on their phenotype and on survivin upregulation.Semantic proximity Read ↗

BCL-2 family protein expression and platinum drug resistance in ovarian carcinomaSemantic proximity Read ↗

Altered Death Receptor Signaling Promotes Epithelial-to-Mesenchymal Transition and Acquired ChemoresistanceSemantic proximity Read ↗

Chemoresistance to paclitaxel in human ovarian xenografts : the role of apoptosis-regulating proteinsSemantic proximity Read ↗

Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatmentSemantic proximity Read ↗

Class III beta-tubulin overexpression is a prominent mechanism of paclitaxel resistance in ovarian cancer patients.Semantic proximity Read ↗

Bcl-2 overexpression sensitizes MCF-7 cells to genistein by multiple mechanismsSemantic proximity Read ↗

Cytoskeleton and paclitaxel sensitivity in breast cancer: the role of beta-tubulins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.