Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unlike esophageal squamous cells, Barrett's epithelial cells resist apoptosis by activating the nuclear factor-kappaB pathway.

Cancer research - 15 Jan 2009

Hormi-Carver Kathy, Zhang Xi, Zhang Hui Ying, Whitehead Robert H, Terada Lance S, Spechler Stuart J, Souza Rhonda F

Abstract excerpt

Apoptosis is an important mechanism for maintaining tissue homeostasis and for preventing the proliferation of cells with mutations that could result in malignancy. Barrett's epithelium has been reported to be more resistant to apoptosis than normal esophageal squamous epithelium. We have explored the contribution of the nuclear factor-kappaB (NF-kappaB) pathway to apoptotic resistance in non-neoplastic,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Barrett Esophagus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to Epithelial Cells

Share to Gastroesophageal Reflux

Share to NF-kappa B

Share to Proto-Oncogene Proteins c-bcl-2

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 19147583
DOI: 10.1158/0008-5472.CAN-08-3703
PMCID: PMC2629390

Genes

NES
XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unlike esophageal squamous cells, Barrett's epithelial cells resist apoptosis by activating the nuclear factor-kappaB pathway.PMID 19147583Read ↗

Expression of apoptosis-related proteins in Barrett's metaplasia-dysplasia-carcinoma sequence: a switch to a more resistant phenotype.Semantic proximity Read ↗

Characterization of telomerase-immortalized, non-neoplastic, human Barrett’s cell line (BAR-T)Semantic proximity Read ↗

Apoptosis in human papillomavirus16 E7-, but not E6-immortalized human uroepithelial cells.Semantic proximity Read ↗

Role of NF-kappaB in the apoptotic-resistant phenotype of keratinocytes.Semantic proximity Read ↗

Role of Bcl-2 family proteins (Bax, Bcl-2 and Bcl-X) on cellular susceptibility to radiation in pancreatic cancer cells.Semantic proximity Read ↗

Apoptosis and cell proliferation in the metaplasia-dysplasia-carcinoma-sequence of Barrett's esophagus.Semantic proximity Read ↗

Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice.Semantic proximity Read ↗

Fas-independent apoptosis induced by UVC in p53-mutated human epithelial tumor A431 cells through activation of caspase-8 and JNK/SAPK.Semantic proximity Read ↗

Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis.Semantic proximity Read ↗

Inhibition of NF-kappaB sensitizes A431 cells to epidermal growth factor-induced apoptosis, whereas its activation by ectopic expression of RelA confers resistance.Semantic proximity Read ↗

Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53.Semantic proximity Read ↗

Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.