Article
Occurrence of TRGV-BJ hybrid gene in SV40-transformed fibroblast cell lines.
Genetica - 1 Jul 2009
D'Arce L P G, Bassi C L, Fachin A L, Passos G A S, Sakamoto-Hojo E T
Abstract excerpt
Illegitimate V(D)J-recombination in lymphoid malignancies involves rearrangements in immunoglobulin or T-cell receptor genes, and these rearrangements may play a role in oncogenic events. High frequencies of TRGV-BJ hybrid gene (rearrangement between the TRB and TRG loci at 7q35 and 7p14-15, respectively) have been detected in lymphocytes from patients with ataxia telangiectasia (AT), and also in patients with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
