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Article

Even at 100+: Acute Exercise Modulates Inflammatory Pathways in Centenarians

15 Jul 2025

Abstract excerpt

Centenarians exhibit remarkable disease resilience despite chronic low-grade inflammation. We investigated the inflammation-related proteome response to acute exercise in seven centenarians (100-104 years). Exercise downregulated 52 proteins (e.g., TNF, IL10, IL1RN, CCL family members) involved in immune cell trafficking, apoptosis, and cytokine regulation. Even at the extreme end of the lifespan, humans retain...

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PMID: 40874701
DOI: 10.1111/acel.70152

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