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Chemoprevention of Colorectal Neoplasia by Estrogen: Potential Role of Vitamin D Activity

1 Jan 2009

Abstract excerpt

Postmenopausal hormone replacement therapy lowers colon cancer incidence. In humans, the mechanism is unknown, but animal models suggest that it may involve activation of the vitamin D receptor (VDR) pathway. The aims of our study were to determine whether estrogen intervention affects global gene expression in rectal mucosal biopsies and whether vitamin D-related genes are affected. Estradiol was given to raise...

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PMID: 19139017
DOI: 10.1158/1940-6207.capr-08-0103

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