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Article

Intratumoral epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells.

Cancer prevention research (Philadelphia, Pa.) - 1 Aug 2008

Zhang Jie, Iwanaga Kentaro, Choi Kuicheon C, Wislez Marie, Raso Maria Gabriela, Wei Wei, Wistuba Ignacio I, Kurie Jonathan M

Abstract excerpt

Non-small cell lung cancer (NSCLC) cells with activating epidermal growth factor receptor (EGFR) somatic mutations have unique biological properties, including high expression of the ErbB ligand epiregulin; however, the biological role of epiregulin in these cells has not been elucidated. To examine its role, we used an immunohistochemical approach to detect epiregulin expression in NSCLC biopsy samples and...

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Identifiers

PMID: 19138957
DOI: 10.1158/1940-6207.CAPR-08-0014
PMCID: PMC3375599

Genes

EGFR
EREG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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