Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epiregulin reprograms cancer-associated fibroblasts and facilitates oral squamous cell carcinoma invasion via JAK2-STAT3 pathway

24 Jun 2019

Abstract excerpt

BACKGROUND: Local resident normal fibroblasts (NFs) are the major source of cancer-associated fibroblasts (CAFs), which are distinguishable from NFs by their tumor-supportive properties. However, the mechanism and the effects underlying the transition of NFs to CAFs in oral squamous cell carcinoma (OSCC) remain unclear. METHODS: Five pairs of matching primary NFs and CAFs derived from OSCC patients were sent for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to HER2/EGFR in Cancer Research
Share to Proteoglycans and glycosaminoglycans research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31234944
DOI: 10.1186/s13046-019-1277-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epiregulin reprograms cancer-associated fibroblasts and facilitates oral squamous cell carcinoma invasion via JAK2-STAT3 pathwayPMID 31234944Read ↗

Identification of Two Distinct Carcinoma-Associated Fibroblast Subtypes with Differential Tumor-Promoting Abilities in Oral Squamous Cell CarcinomaSemantic proximity Read ↗

Roles of E2F family members in the diagnosis and prognosis of head and neck squamous cell carcinomaSemantic proximity Read ↗

Human telomerase reverse transcriptase (hTERT) promotes cancer invasion by modulating cathepsin D via early growth response (EGR)-1Semantic proximity Read ↗

Epiregulin enhances tumorigenicity by activating the ERK/MAPK pathway in glioblastomaSemantic proximity Read ↗

TERT drives fibroblasts reprogramming to promote the invasion of head and neck squamous cell carcinoma via transferring of exosomal MET proteinSemantic proximity Read ↗

EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapy.Semantic proximity Read ↗

Cancer‐Associated Fibroblast Heterogeneity in Oral CancerSemantic proximity Read ↗

Identifying the oncogenic roles of FAP in human cancers based on systematic analysisSemantic proximity Read ↗

Cancer-Associated Fibroblasts Modulate Transcriptional Signatures Involved in Proliferation, Differentiation and Metastasis in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Fibroblasts—a key host cell type in tumor initiation, progression, and metastasisSemantic proximity Read ↗

Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer.Semantic proximity Read ↗

Single-cell RNA sequencing of OSCC primary tumors and lymph nodes reveals distinct origin and phenotype of fibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.