Article
Phylogenetic reconstruction of transmission events from individuals with acute HIV infection: toward more-rigorous epidemiological definitions.
The Journal of infectious diseases - 1 Feb 2009
Brown Alison E, Gifford Robert J, Clewley Jonathan P, Kucherer Claudia, Masquelier Bernard, Porter Kholoud, Balotta Claudia, Back Nicole K T, Jorgensen Louise Bruun, de Mendoza Carmen, Bhaskaran Krishnan, Gill O Noel, Johnson Anne M, Pillay Deenan
Abstract excerpt
Phylogenetic reconstructions of transmission events from individuals with acute human immunodeficiency virus (HIV) infection are conducted to illustrate this group's heightened infectivity. Varied definitions of acute infection and assumptions about observed phylogenetic clusters may produce misleading results. We conducted a phylogenetic analysis of HIV pol sequences from 165 European patients with estimated...
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