A common variant of the eNOS gene (E298D) is an independent risk factor for left ventricular hypertrophy in human essential hypertension.

doi:10.1042/CS20080476

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Article

A common variant of the eNOS gene (E298D) is an independent risk factor for left ventricular hypertrophy in human essential hypertension.

Clinical science (London, England : 1979) - 15 Jun 2009

Xin Ying, Song Xiaodong, Xue Hao, Liu Zhe, Wang Xiaojian, Wang Hu, Sun Kai, Bai Yongyi, Liu Junhao, Hui Rutai

Abstract excerpt

eNOS (endothelial NO synthase) plays a critical role in the development of ventricular remodelling and cardiac hypertrophy. The purpose of the present study was to determine whether three common variants in NOS3 (the eNOS gene) are associated with the risk of LVH [LV (left ventricular) hypertrophy] in patients with essential hypertension. Three NOS3 genetic variants, -T786C (rs2070744), eNOS4a/b and +G894T...

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Identifiers

PMID: 19132956
DOI: 10.1042/CS20080476

Genes

NOS3

Variants

rs2070744
rs2070744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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