Article
An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9.
Molecular vision - 11 Aug 2010
Goldstein Orly, Mezey Jason G, Boyko Adam R, Gao Chuan, Wang Wei, Bustamante Carlos D, Anguish Lynne J, Jordan Julie Ann, Pearce-Kelling Susan E, Aguirre Gustavo D, Acland Gregory M
Abstract excerpt
PURPOSE: To identify the causative mutation in a canine cone-rod dystrophy (crd3) that segregates as an adult onset disorder in the Glen of Imaal Terrier breed of dog. METHODS: Glen of Imaal Terriers were ascertained for crd3 phenotype by clinical ophthalmoscopic examination, and in selected cases by electroretinography. Blood samples from affected cases and non-affected controls were collected and used, after...
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