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Article

IQCB1 and PDE6B mutations cause similar early onset retinal degenerations in two closely related terrier dog breeds.

Investigative ophthalmology & visual science - 25 Oct 2013

Goldstein Orly, Mezey Jason G, Schweitzer Peter A, Boyko Adam R, Gao Chuan, Bustamante Carlos D, Jordan Julie Ann, Aguirre Gustavo D, Acland Gregory M

Abstract excerpt

PURPOSE: To identify the causative mutations in two early-onset canine retinal degenerations, crd1 and crd2, segregating in the American Staffordshire terrier and the Pit Bull Terrier breeds, respectively. METHODS: Retinal morphology of crd1- and crd2-affected dogs was evaluated by light microscopy. DNA was extracted from affected and related unaffected controls. Association analysis was undertaken using the...

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Source

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Identifiers

PMID: 24045995
DOI: 10.1167/iovs.13-12915
PMCID: PMC3809947

Genes

IQCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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