Article
Association between p53 codon 72 genetic polymorphism and tobacco use and lung cancer risk.
Lung - 1 Jan 2000
Cáceres Dante D, Quiñones Luis A, Schroeder Jane C, Gil Leonel D, Irarrázabal Carlos E
Abstract excerpt
Lung cancer (LCa) is the leading cause of death by cancer in men. Genetic and environmental factors play a synergistic role in its etiology. We explore in 111 lung cancer cases and 133 unrelated noncancer controls the gene-environment interaction (G x E) between p53cd72 polymorphism variants and smoking and the effect on LCa risk in two kinds of case-control designs. We assessed the interaction odds ratio (IOR)...
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