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Article

Genome-wide identification of genetic determinants for the cytotoxicity of perifosine.

Human genomics - 1 Sept 2008

Zhang Wei, Liu Wanqing, Poradosu Enrique, Ratain Mark J

Abstract excerpt

Perifosine belongs to the class of alkylphospholipid analogues, which act primarily at the cell membrane, thereby targeting signal transduction pathways. In phase I/II clinical trials, perifosine has induced tumour regression and caused disease stabilisation in a variety of tumour types. The gene...

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Identifiers

PMID: 19129090
DOI: 10.1186/1479-7364-3-1-53
PMCID: PMC3525180

Genes

EXOC4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19129090-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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